Heterozygote advantage as a natural consequence of adaptation in diploids
نویسندگان
چکیده
منابع مشابه
Heterozygote Advantage for Fecundity
Heterozygote advantage, or overdominance, remains a popular and persuasive explanation for the maintenance of genetic variation in natural populations in the face of selection. However, despite being first proposed more than 80 years ago, there remain few examples that fit the criteria for heterozygote advantage, all of which are associated with disease resistance and are maintained only in the...
متن کاملHeterozygote Advantage Is a Common Outcome of Adaptation in Saccharomyces cerevisiae.
Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently, we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the population but then, instead of bringing them to fixation, should maintain them as balanced polymo...
متن کاملNo Heterozygote Advantage in Fallow Deer
Effects of inbreeding on individual fitness are of long-standing interest in evolutionary biology and conservation studies. Since estimation of the inbreeding coefficient of a given individual is often impossible in wild populations, some authors have attempted to demonstrate inbreeding depression in such populations by correlating the multi-locus marker heterozygosity of individuals with a tra...
متن کاملHeterozygote advantage for the phenylketonuria allele.
Mean weight at birth of unaffected (normal homozygous and PKU heterozygous) offspring of parents heterozygous for the phenylketonuria (PKU) allele averages significantly above that of Norwegian neonates, with no significant difference in mean age of mothers or in mean parity. It approaches the optimal birthweight--that which confers the minimum overall mortality in the pre-, peri-, and postnata...
متن کاملHeterozygote advantage and the evolution of a dominant diploid phase.
The life cycle of eukaryotic, sexual species is divided into haploid and diploid phases. In multicellular animals and seed plants, the diploid phase is dominant, and the haploid phase is reduced to one, or a very few cells, which are dependent on the diploid form. In other eukaryotic species, however, the haploid phase may dominate or the phases may be equally developed. Even though an alternat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1114573108